The fixed-length of the resonators, and of any conventional headers, whether equal-length, 3-2-1, shorty, whatever, that is my point of departure. I have two small ideas on this.
In my long-ago youth, I raced outboards, and these included alky-burning 2-stroke exotics whose modification was limited only by displacement and natural aspiration. This began in the fairly early days of expansion chambers. Suspending expansion chambers on a racing outboard motor is far easier than trying to hang them on a motorcycle, kart, or sled; generally you have an exhaust stub coming sideways out of the powerhead, making a short 90 degree turn to the rear, and the megaphone(s) or expansion chamber(s) point straight aft, with some bracing arranged to support them. This made pipe-building much simpler for boats than for bikes, etc..
Well, since almost all of the exhaust was in a straight line pointing aft, smarter guys than I figured out that the pipes did not have to have a fixed length. You could make them with a sliding section, nearly always in the header stub immediately after it had turned aft and immediately before the first diffuser cone in the expansion chamber. You could get up to about 4" of travel, shortening and lengthening the tuned length of the pipe, which moved the torque peak up and down the rpm range a small but useful amount. By attaching a bowden cable to the pipe and to a lever in the cockpit, the driver could pull the pipe in (shorten the tuned length) or let it out. Coming off a turn, with the engine loaded down, he'd let the pipe go full-travel out, lowering the rpm of the torque peak. As the boat got going faster and faster down the straightaway, he'd pull the pipe in, raising the torque peak. Pretty cool, and something you couldn't do on a bike.
Do you see what I see? On a car, with possible exceptions of those with transverse-mounted 4-cylinder engines, you'd have a tough time devising any kind of conventional full-sized exhaust header with sliding sections. But if what you had was a shorty header, such as the EFI manifolds from the late 300s, in conjunction with a resonator (or two, in the case of those EFI manifolds), it might be easy to incorporate a sliding section in just the resonator. No, I'm not suggesting this be driver-controlled as in our hydroplanes (although you could do this for dyno testing). You would mark the sliding section in increments, clamp the resonator in place, go make your test run or your pass, re-clamp the resonator at a new point, and try again.
My contention is that this is a whole lot better way to get dialed-in than building a fixed exhaust with the guidance of some software program. When you hit the best all-around length of resonator, you could weld it in place . . . or just clamp it there, in case you make future alterations (cam changes?) that could call for re-testing. Obviously, this procedure is conceptually simple and takes many hours to actually do. For one thing, you'd have to chase the the exhaust alterations around with timing curve tests to get the full benefits. But if you're a real zealot, or a weekend racer, it might be more fun than golf.
My add-on idea: When Smith and Morrison were doing there cut-weld-and-tests with resonators, they terminated their resonators in flat plates. This flat cap on the end of the tube certainly gave them the strongest wave action and the most dramatic effects when testing the resonators. But, as any 2-stroke guy knows, a flat plate not only makes the effect strong, but peaky, that is, very effective over a very small rpm band. This might be okay in racing, but is terrible for a street car. So my idea is that after you do your testing while sliding the reasonator in and out, you take it off and cut out the flat end-cap, and weld a long-tapered cone in its place. This will weaken the effect of the resonator while greatly widening the rpm band in which it works, both of which are what you'd want in a street machine.
What do all you brainy guys think of it?
P.S. For SoldMy66, if all you want to do is put a resonator out in the exhaust pipe to damping a droning noise, the sliding idea would be real easy to do and test.