4.1/3.3 250/200 x-flow fits nicely with the XC onwards Crossflow radiator or a bigger Aussie Desert Cooler.
When a Supercharger is put in, the shock braces need rework, but on a non crossflow, you can get it all packaged if you use some smarts.
2V and Log head 250 has a really tall fan and water outlet, and Crossflow radiator or a bigger Aussie Desert Cooler just allows it to fit, but its the top of the carb that causes the problem. Earlier rocker cover and the Cleveland style oil filler allows the carbs air cleaner to sit lower.
The 221/188 are only a little taller than the 144/170/200, but a 2v or classic inlines intake and head fits great.