Probably the most cost effective way to put EFI on a 200/250 would be to use the GM TBI system with a 1227747 ECU.
The 2bbl from a 4.3 would be close enough to the HP of either one that you could get it tuned to run well. The duraspark distributor can be modified to lock the advance, delete the vacuum advance, and hooked to a GM 7-pin ignition module for timing control.
Use a 87-91 GM truck junkyard harness, add the coolant, knock, and MAP sensor. Discard the wiring for the EGR, torque converter clutch. You can add the A/C, vehicle speed sensor. You would need an EFI fuel pump and return line.
A stock 4.3 chip would probably get the engine running and might actually run well.
They toss these things onto almost everything and they seem to work well. I've seen one on a flathead V8, a Chevy inline six, a corvair, and all kinds of other oddball engines.