For the cost, there is no benefit in doing a stroker 250. But heres how to do it.
Excuse the mix of metric and imperial. Most rods are measured in inches because the Americans are the only people who give a damn.
The physical limit for stroking a 250 would be a 4.125" stroke, which, with a 60 thou over bore, could make 272 cid, or 4456 cc's. This is a 9% increase, roughly equal to going from a 245 to a 265 in a Valiant Hemi.
The only way this sort of stroker can be done is by finding a Honda or Mitsubishi style con-rod that has a ~48 mm, or 1.9" journal. You then offset grind the crank journals by making them smaller, and effectively move the throw of the rod out 2.7 mm, for a 5.5 mm stroke increase.
There are six inch, 2.0" journal Chevy rods, but the stroke would be limited. 266 cubes with +60 thou pistons. Some of the 4G52 Astron rods are good prospects (2.048" or 52 mm journal), but the stroke increase is even less. 263 cubes.
There is also the prospect, at huge expense, of using the latest GM4200 crank in the Ford 250 block. But that would be a massive under taking. It has a stoke of around ~4.06 inches or so, and is based on the same centres as the Ford.
Either option places the cam very,very close to the rods. The base of the cylinder bores would have to be shaved, and the rods would have to have the bolts ground to avoid doing a kamakazie job on anything that is in the way.
After investing a few thousand grand in the offset grind of the crank, a thousand in bolts and con-rods, you end up with a weaker crank which needs some specialised work on the fillet radius to ensure it can be strentghened enough for hi-rpm work. Then you need short deck pistons so the longer rod and stroke can mix it inside the block.
You may get a 6.38" rod from somewhere, and six custom Wiesco pistons with a 1.00" deck register to maintain a fair rod to stroke ratio, in order to stop side loading the bores. This is a wooping 0.600 inches shallower than the stock piston, and risking the integrity of the rings.
The real issue is that the 250 block is an engine stroked and bored within an inch of it's life. It started off as a 2.365 liter engin of 144.3 cubes, and became 73% bigger with virtually no major block mods aside from raising the deck of the block and increasing the main bearing numbers and sizes.
If someone minted a siamesed bore version of the 250, using a 3.775 to 3.835" bore, with a great steel crank of 4.125" stroke, there is a 277 to 286 cube engine in there.Your attention should be drawn to the bigger 300 US Bronco/F-series truck six. With an offset grind, there is a 330 cube engine there, with torque to move a mountain, and a bunch of brilliant gearboxes to match.
Things like 265 Hemis can be bored ,with some risk, to 282 cid. The 250 Chev L6 can be taken out to 292 cubes, or even 312 cubes with minor risk.
All have more space between the bores than the 144 to 250 Fords, the 300 and 250/292 have more block height, and all have more potential for block stability under load than the 250.