The Holley 2300 500 cfm carb will work perfectly on a wild 250 cube 2V engine. My ex next door neighbour had a Chrysler Valiant Charger Hemi 265 with one.
(This was a Plymouth Valiant sedan with 105 inch wheelbase, repackaged as a Challenger -style sports back. Engine was a sort of Chevy 250 -style straight six with Hemi head and came stock with 2 barrel carb. optional triple Webers. 14.4 second 1/4 mile times!)
His car had an E38 cam which had 272 degrees duration. He tried a 2100 Autolite, which he rated as a better carb, but couldn't re-jet it easily because we Kiwis don't have parts back-up for them. So he got a Holley. Problem is, the 2300's have a nastyvertical split line between the float bowel that leaks fuel when you work on them, or sometimes during normal use. Autolite 2 barrels have a horizontal split line, that does't leak as easily. And some were annular discharge, which is more efficient. As for me. I just use the Holley 2300 #4412 500 cfm throttle body on my ride...the LPG carb meters propane to it, and leaks aren't an issue!
.