Howdy 65 six:
The rough idle you describe is likely not the main jets size. That is the idle circuit. We typically have to turn the air screws out three full turns to get away from a too lean idle condition of 2100s on 200s and 250s.
You didn't say what 2100 you are using. What car did it come off of? What distributor are you using? The idle circuits varied greatly even in the same size 2100. These carbs may be the simplist carb ever to rebuild.
Assessing main jets is one of the last carb tuning steps we do. More often than not, the main jet does not need to be changed, and then only a size or two. Before you start on the carb, make sure the ignition is in the best shape possible. 1st assess and tune the idle, next transitions, cruise and then Wide Open Throttle (WOT). The main jets are not much visible until highway cruise speeds are reached or at WOT.
Before you begin assessing main jets, again, make sure your ignition is in tip-top shape.
At a cruise, at steady throttle, if your engine surges or "hunts" as in won't stay at a steady rpm you are likely lean. Verify this by checking the spark plugs for signs of glazing or white hot ashing. Before you decide to change jets, make sure the carb is clean and all orifaces and channels are open.
For too rich, look for black smoke out the tail pipe and black or wet plugs.
When assessing for WOT, it is best to start with a fresh set of the correct heat range spark plugs. Have the engine completely warmed up and no choke. Then do a WOT acceleration run, in 2nd gear from 2,500 to 4,500. Immediately shut off the engine, stop the car and pull several plugs to assess. You are looking for a light tan color on the porcelain. Lighter is lean, darker color is rich- or possibly a sign of other problems, like oil contamination.
Many factors effect optimum jetting- things like temperature- ambient and engine, barametric pressure, humidity, elevation, quality and condition of ignition and engine. So don't get too anal. In general, it is best to jet slightly on the rich side, but optimum power tends to be achieved on the lean side- BUT- so does engine damage so be careful.
That should get you started.
Adios, David