Howdy Back Ralf:
To answer your question, YEs, it is worth it if you are looking for any level of increased performance! I've upgraded a '65 200 with an 1101 and '68 point distriburtor and also tried a Carter RBS. I've tried funnel adapter with 2100s too. Nothing is as significant as a direct mounted wide base two barrel. I cannot accurately quantify how much better because while the head was off I cleaned and shaped the ports, polished the chambers, milled, installed a port divider, had a three angle seat, back-cut the intake valves and modified the exhaust manifold. Oh, and added a direct mount 2V opening. The two barrel conversion also included a conversion to a Maverick throttle pedal and cable, adapting and rerouting the gas line. That was on a stock '65 200 block. The difference, with an Autolite 1.08 over the 1101 was night and day. Later the head got a clean up and was installed on my current 250 built block along with a DS II and a single outlet header. Since then, it has had several sizes of 2100s, currently a 1.33, and a Holley 500 (#4412).
My truck is a daily driver, with an SROD 4 speed and a 3:1 8" rear. It is not intended to be a race car, but I do enjoy an ocassional bout of spirited driving. Oh, and it also gets good mileage with a 1.08- 16-17 in town, and 21-23 on the highway. Another advantage of the 2V mod is the wide variety of carbs to choose from and the ease of swapping and tuning. Stock hood clearance is another bonus. I've adapted an aluminum Climactic air cleaner system from an 80's LTD with the lid chromed, added a chromed "Powered by Ford" valve cover to ease throttle cable adjsuting, and it looks like something FoMoCo should have done.
So, again, Yes, it is worth it, but the mod will likely provide you with an opportunity to do several upgrades while the head is off- all worth doing. It is hard to pull out the costs related to the 2v mod because other stuff was done at the same time/bill. My total bill for the head work back then, about 8 years ago, was $270. It would be safe to say that the 2V conversion would be about half of that. In today prices, I'm sure it woule be more.
That's my two cents, for what it's worth.
Adios, David