Yes, it can be done, but there were
two types over the years, and 250 is different to 200, even though the headers are usually a one size fits all design. You have to see where the air pump is, then see if you can clear the low mount a/c unit used on L and C-code 250's.
First was York/Tecumseh upright (later branded as Motorcraft)
Second was the Fridgidaire A6
Third option, are Sanden retro fit for the York/Tecumseh and found standard in later Australian Ford Falcons/Fairmonts/Fairlanes/LTD's
The easiest to shift from any header system is the octangonal 8 bolt plate York/Tecumseh. The Frigidaire Type A6 is more likely to collide with the header, and is most likely hardest to move away. Headers do take up more space.
Type 1 : The stock York/Tecumseh 1969-1979 T-code X-shell and S-shell(Fox) and 1980 to 1983 B-code 200/ 3.3 six system pretty well locked down. Its the same as these (82 Granada 1st two, Mustang 2nd one):


Type 2: X-shell for US 250 up to 1970.5 to 1980. This is a Monarch 4.1, last year made. Typical of Fords engineering, they swapped air pump and a/c positions between the Fox body and X-cars. Early 4.1 and 250's generally followed the V8 York or Techumsehr air con pump position on drivers side, but from 1976, a Frigidaire Type A6 low mount passenger side air con unit was used.

L-code 250's (1968-1979) and C-code 4.1's (1980-1981) were interesting in that Ford did some major A/C and air pump changes in the X-shell and later full frame Torino bodies it sat in. You can mix and match bits, but both 3.3's and 4.1's need massaging to fit headers.
With the air pump gone, here is what the long low mount L-code Frigidaire Type A6 a/c pump is like
The earlier X-shells ran a 200 style York/Tecumseh A/c pump, shorter than the Frigidaire Type A6, but mounted high on the passenger side like in the S-shell Fox bodies. If you were able to swap to the harder to find 1970.5 Falcon and earlier Maverick 250 ancillary set-up, you'll gain the space you seek.
