Howdy Kenny and All:
The Motorcraft/Ford 2150 appeared in 1975 as part of the lingering demise of the Autolite Co. As previously mentioned it was modified to try to achieve EPA goals for Ford vehicles. While it maintained all of the pluses of the earlier 2100 it also added a VV (Variable Venturi) function which was a sliding rod in the high speed air bleeds. The intent was to make a cleaner carb through the throttle range. IF you will need to get into tuning air bleeds for your application, this complicates the process. Overall, the 2100 is cleaner, weighs less and is easier to tune.
However, If you've go a good 2150, use it.
Adios, David