Pretty easy, but I'd not try it.Talk to drag 200 stang first. He did it in his 250 blocked turbo mustang in the 80's
You either
1. run machined spacers like the 400 Chev engines with 302/327/350 cranks used to use, just remade babit bearing shells in steel.
2. Or run the 200 US crank it in a lathe, and downhand stick weld extra iron on the main bearings, and weld up the front and back parts from the stock size to 250 size. The crank flange on all 250's is the v-8 flange, and the US 200 runs the stock 3.622" diamter flange, so there is just a lot of welding, and then fillet radius grinding. The front flage needs to go up from 1.242 or near offer, to about 1.375" via a special tube or welding.
3. Or use an Aussie Falcon 200 crank from the 1972 to 1992 engines.
4. Or cut off the 250 flange, and make a spigot, and weld that to the 200 crank.
A lot of work to loose 25% of your engine capacity. Then you'll need some 300 Big six rods or early 0.912" wrist pin 6.242" 240 rods.