Should be no problem in a Comete
The 250 saw duty in many X-cars (that is, all cars which had coil over A-arm unibody chassis, based on the first XK 2000 Falcon, and last field in the US in the 1979 Granada). They were all front sump.
The last Torinos had a 250 base engine for a couple of years, a full chassis, and were not X-bodies. They should have rear sumps. Jack posted his 250 in Fox Mustang link last year with a 250 Triple Carb candy apple colored six. It had welded up dual out headers, and a cut and shut sump using two 250 sumps to clear the rack and pinion steering in the Fox, and the front cross-member.
The 250 was designed to fit in the same envelope a 302 fits into. Generally, where a 302 goes, a 250 will too, unless it has a restricted firewall like a Pinto, Mustang II, or British Cortina.