The 2100 is a good carb.
It has a few tuning quirks. Normally on a carb, you would turn out the air mixture screws about 1 1/2 to 2 turns. We've found that they need to be out 3 1/2 to 4 turns. You'll have to play with it a bit - but you'd have to play with the Holley too.
When you look at a 2100 carb rebuild spec sheet, you'll see that they have several different float level settings depending on the factory application. I use the highest factory float setting on my 200. David (brother) uses a middle of the road setting for his 250. Like I say, you'll have to play a bit to match your application - but that's the gratifying part.
There's no difference between the auto and the std. carbs - other than some added stuff like the dashpot. However, would avoid the later 2100 that had electronis sensors - If its got wires coming out of it anywhere (other than the choke), find a carb without wires.
Look at both of the carb jets sizes. If they are different, try playing with them as you fine tune the carb.
PS At cruise night, when I pop my hood, my carb is ALWAYS a 500 cfm two barrel. It's better to exaggerate on cruise nights, than to have a foul running car the rest of the week.