Howdy Back FastRonald:
A couple of things; 1st read the sticky post at the top of this forum for details on the difference of compressed thickness of head gaskets, 2nd, all 200/250 casting are the same. For example, a head with a D3DE-AA casting # from 1973 and after would be used on either a 200 or a 250 block. The difference in compression was in the deck height, And 3rd a head from an '81 block would likely have an E0BE casting mark and a chamber volume of aproximately 62 cc.
So to be accurate and specific, what is the casting # of the "250" head you plan to use? And Doug's advice to CC the chamber of the "250" head is right on. You never really know what has been done to a head in the last 40 years and the only way to know for sure is to measure it yourself.
Adios, David