Howdy Swanson and All:
If you are rebuilding the short block, consider reducing or eliminating the massive deck clearance found in 250s. Mine had .150" of deck height. Consider using the pistons from a 255 V8 which will stand .085" taller in the bore than replacement pistons. That would leave .065" which can be reduced by decking, or milling off the top of the block. The aftermarket head gasket will leave more than enough space for valve/piston clearance.
Reducing deck clearance (deck height + compressed gasket thickness) will improve quench and increase turbulence, which will improve combustion efficiency and reduce tendency for pre-ignition.
You will have to open up the combustion chamber in the head to control Compression and keep it in the 9 to 9.5:1 range. Measure all critical dimensions carefully and record. You will also have to use hardened steel washer under the head bolts to avoid bottoming them out in their holes.
Be sure to have the whole rotating and reciprocating assemblies balanced, both static and dynamic balancing. Because of their longer stroke and poor rod to stroke ratio a 250 will have it biggest advantage at engine speed below 5,000 rpms, so choose your cam accordingly.
That's my two cents.
Adios, David