I like the big bore, short stroke combo also. One trick I've tried is to offset bore towards the minor thrust side (driver's side). How much you can go depends on your block and how much overbore you are doing. What this helps is it opens up more room around the valves which is very close to the bores even with stock size valves. It also leaves the major thrust side (passenger's side) with a thicker cylinder wall on the side where you need more strength.
On my new build I have .020 overbore pistons. Trying to keep the cylinder walls as thick as possible. The problem is the head I have was originally on a NA .070 overbore engine which I enlarged the chamber by the valves out to 3 3/4" but now it overhangs the smaller bore. I previously have been notching the bore (old Ford FE trick) but being turbocharged it exposes too much heat to the top ring so I plan on moving the cylinder head over. On the log head, the two end passenger side cylinder head bolt holes are smaller than the rest. They are used to locate the cylinder head and gasket. I plan on offset milling those two holes, maybe a touch of the others about .060, maybe more. Then I'll be able to slide the cylinder head over so the clearanced chamber does not overhang the cylinder bore.
With a reduced crank pin and offset ground for shorter stroke, lightweight vibration absorbing aluminum rods would probably fit without serious clearancing of the cam and lower cylinder wall.
Good luck. As always, get a second opinion.