Howdy 65fall:
In addition to the info you've already gotten from others, the difference is in the block casting. A casting code of C4DE (Used in 1964 & 1965 model years) or a C3DE (Used in 1963 & '64 model years) will likely be a 4 main bearing block, not plumbed for a hydraulic lifter type cam, and a smaller distributor drive shaft from the oil pump and a smaller distributor hole in the block. A C5DE code, ocassionally seen in '64 model year vehicles will be the later, 7 main bearing engine. 1964, '64 1/2, and '65 were major change years for the 200 engines. Also complicated by FoMoCos "empty bin" policy.
The differences equate to choices. The later blocks capable of using hydraulic lifter type cams offer many more cams to choose from. The same is try for distributor options. The earlier blocks can be modified by retro fitting a later oil pump with the larger distributor driveshaft, and the block hole enlarged for the later style distributor.
A 7 main bearing crank will be much more durable at higher rpms and power levels.
That's the details. You have to decide what's best for you.
Adios, David