Howdy Nathan:
We've been down this road many times before on this forum. Try a search first for more basic information.
Then try narrowing your search by defining "Better".
Both Holley 2300 and Holey/Weber 5200 are quality carbs and they do an excellent job at what they werde designed to do.
In general the Holley 2300, in either a 350 (350 CFM) or 500 (500 CFM) size will-
*have a stronger top end.
*be easy to work on and tune.
*be able to be tuned for good economy and driveability.
In general, the Holley/Weber (235 - 270 CFM)will-
*give good idle quality, driveability and economy.
*give slightly more performance.
*be able to be tuned to most any situation.
Both would benefit from direct mounting. Either can be mounted using an adaptor. Both will require a different or modified air cleaner, fuel lines, linkage and vacuum hose attachment. Both can offer a ported vacuum source.
What's "better" for you?
Adios, David