The 250 suffers from an extremely low (negative) deck height. The piston is over .120" down in the cylinder at TDC, so there is no quench effect and very low compression.
There are a couple of ways to remedy this. The first, which I employed on my own 250, was to use 255 V8 pistons. They are .085" taller than the 250 pistons, allowing you to cut the block .035 - .040" to get a zero deck height. Then by relieving the combustion chambers, you can get a reasonable compression ratio and decent quench area.
The second method would be to use a longer 2.5 HSC rod with the stock piston. This has the advantage of giving you a slightly better rod/stroke ratio. I have not tired this, but the numbers are right. The deck should still be surfaced and you would still have to relieve the chambers to get the CR down to a reasonable level.
Either way you have to have a cooperative machine shop that will allow you to assemble and measure assemblies along the way.