Howdy Nick:
What is the casting number on the 250 head you're working on?
Much of the grinding and detail fitting can be done at home, but it will take a pretty sophisticated home shop to do the machining and weld fill-in required for the two barrel conversion. While I appreciate DIY and homebuilt, it is good to know when you need help and where to get it. You might want to make a decision on if you intend to use an exhaust port divider on the center exhaust ports as it requires welding to properly fit it. There are differing opinions on the performance value of the divider. Do a search and decide for yourself. My only advice is that if you're going to add it do it right and have it welded in.
It is a good idea to get all of the milling, fitting and welding done prior to any detailed finish work because cracking can occur during welding and/or grinding. And, distortion/warping can occur during the heating and cooling process of welding. You would not be happy if you do hours of detailed hand work only to find a fatal crack.
Bill hit the high point on building a performance head- all good stuff. Enjoy.
Adios, David