Drilling is okay for 1-bbl carbs, but its a very bad idea for 2-bbls. Any time you drill a jet, you hurt the chamfer, and the jet doesn't always flow better than the orginal undrilled. The reason is that even close limit jets from Holley have a variance of not more 4.5% in flow rate, and you drill, the internal smoothness and chamfer and resulting flow rate cna drop.
As an example. A 2150 Holley with two 53 jets will be worse when drilled out as the chamfer comes of the jet when drilled, and the calibrated variance will be greater when drilled.
If its a 1-bbl carb, go for it, but if you drill it out a lot, you'll have to re-establish the 60 degree include angle chamer by another process.
For me, Pony carbs 8 bucks a jet is just fine.