Howdy Jim:
There are lots of opinions on this subject here on this forum. There are also lots of shared experiences. Before you will get any specific, practical insights, you will need to give more information about your goals and intended out come for your vehicle. I could offer you lots of info on the 2100, but little on the 5200. The big generality is that the 5200s offer improved driveability, better MPG, and a slight increase in performance. However, a 2100, properly sized and tuned, can give all of that and more of a power increase. Some have found the 5200 hard to tune and finnicky.
The 2100 came into use in the 1957 model year and remained until 1974 when it was upgraded(???) to the 2150. The downside of the 2100 is that they are no longer in production. They are only available as rebuildable cores or rebuilt. Since they were the standard carb on millions of 221s, 260s, 272s, 289s, 292s, 302s, 351s, 352s, 390s & 429s finding a good core is fairly inexpensive and relatively easy. Rebuild kits are easy to acquire, and the 2100 may be the easiest ever carb to rebuild. They are available in eight sizes ranging from 190 to 424 cfm. The 2100s are fairly sturdy, lighter than a Holley 2300, have no gasket lines below the fuel level, and are fairly easy to tune.
Both will require a '68 and later distributor which utilizes a ported vacuum source to work as designed. Both will require adapting the mount, fuel lines, and linkage. And require a non stock air cleaner. Mike's website has dyno info on the 2100s by size and application. I don't recall seeing dyno info on the 5200 but it may also be there. Check it out.
Now, how about some more of your details?
Adios, David