Howdy Doc:
A '65 Falcon Ranchero, 3,000 lbs, 250 engine with an SROD 4 speed, 3.50:1 rear gear, modified log head with a direct mounted 1.08 Autolite two barrel, 2.05x70x14" tires, DS II ignition, header.
I use a circuit to get a quick and dirty mileage measure to assess changes. It is a 66 mile loop which is mostly on I15, with some easy traffic. I fill the same way, at the same station, with the same gas-drive the loop at the same speeds and refill at the same station where I started. Last test was about a year ago. it averaged out to 24.5 mpg.
My base line about 5 years ago was with the original (When I got it) 200 with the stock 3 speed, a '68 distributor and an Autolite 1101. It got 22.2.
I just recently switched carbs to a #4412 Holley 2 barrel, and need to do a camparison for mileage and acceleration, before I swap the rear end for a Maverick 8" with 3.00:1 gears.
Mileage is a composite of many variables. While this survey is interesting, your driving style will be an unaccounted for variable. Vehicle weight, engine efficiency, rolling resistance, climate, elevation, type of driving, etc.
If mileage is your goal, mucking up the 428 Bird will not likely get it. You might want to consider keeping the 'Bird as is and buying a lighter, more efficient mileage maker for everyday driving. An early Falcon or Mustang, or a Fox platform Mustang or Fairmont may be just the ticket.
Adios, David