My first upgrade to my car was a H/W 5200 from Stovebolt and a Duraspark 2.
The carb was not jetted correctly for the 6 and bogged really bad on initial WOT acceleration.
It did dramatically smooth the engine out, but I'm sure the Duraspark had a lot to do with that as well.
My next upgrade was installing a D7 250 log with the works, three angle, back cut intakes, port polish, mill, big valves, port divider, etc. and a H/W 5200 that had been tuned to the six. WOW!!! Big difference even without a cam or headers. Like jamyers said much better low to mid range torque, keeping up or entering the freeway is a breeze. Plus you can really hear it sucking when the secondary opens.
Remember flipping the air cleaner top over on Pop's 350 to hear the carb roar when the secondaries opened? Like that.
When you do the cam and header you start to get into real fun.
Bob