The 250 will take a 274 degree Clay Smith cam on the right lobe centre to suit the transmission, and behave well. On a poorly flowing engine, it will not 'come on the cam' like a Twin Cam Supra or GT Corolla. If your effective compression hasn't dropped, then neither will your low end torque suffer.
If your breathing improves in a 250 engine with a cam, it won't get cammy even with 280 degrees duration. I've checked with Kelford Cams, and even the 250 with the much better breathing alloy head is really insensitive to cam duration. The 1987 Falcon 4.1 Litre X-flow with 155 cfm of port flow at 25"H20 was totally happy with a 2.77:1 diff, T5 gearbox, and 280 degree cam on a factory experimental SVO Falcon XF.
Lastly, the 250 is a long stroke, short rod engine with small heads and the info from my sources in the industry say that at 270 degrees, emissions starts to suffer, at 280 with a free breathing head and 50 thou lift durations of 215 degrees and a stock stall converter, you'll still be okay. The point where things start to unrevel are the off idle hole when both valves are open 30 thou, and you have a really stiff 1650 stock stall converterand a cam over 280 degrees at lash, or over 220 degress duration at 50 thou. At that point, air flow can suffer reversion, and low end torque can go away an hide, making the car unstable on off idle.
Power steering and a/c also can hurt idle, but its not an issue on this Ford six.
After you've done the cam, the initial ignition advance and total curve ramp will need reworking downwards. Verification of stock curve needs to happen with a dial back timing light, then I'd use the stock placards 9 degrees measured as per Fords requirements, and then peg the total advance back to no more than 34 degrees. That way, you should be able to run 87 octane, and hopefully not suffer pinking under load. A bigger cam helps blead off compression, and if the cold crank value is around 180 psi with the cam degreed, then you'll have a really nice combination.