Its certainly possible. The Holley Weber/Weber DG series is the most versatile carb ever made, and now, one of the most documented.
On a Holley 2300/4150 series, you have any power valve from 2.5 to 10.5, plus dual stages and nothing but one or two types of well tube.
With the Weber DG series,and Holley Weber, they officially have only 3.6 or Lima 8.5 power valve, yet the whole carb is tunable with something like 60 emulsion tubes not including the 5200/6500 one, any jets, any correctors and a brace of three accelerator pump curves and squirter jets from 20, 21, 23 thou. Sometimes you can even pick up a no name 9.0 power valve that fits. The Power Valve channel restrictions (PVCR) vary from 25 thou to 65 thou, and there's a heap of very smart ported vaccum mods to trick the power valve into being operated off the idle circuit to stop the soft tip in as the mechanical secondary can be rather slow to engergize. Then there is the no two alike nature, with the now you see it, now you don't secondary idle ciruit and dobuel booster venturi, and the myriads of types of casting changes.
I learned that to duplicate the Holley Weber calibration in a Holley 7448 350 cfm carb, it needs 16 to 20 thou PCVR's and a 2.5 Power Valve to run on a 2000 or 2300 Pinto engine, so its not a carb with a hugely rich power valve circuit like all 2-bbl Holley 2300 series carbs are. The 4-bbls power valve steps up jetting about 30 to 40%, or 6 to 8 jet call sizes, but the 2-bbls richen up about 60%, or 11 call sizes. The Weber DG and Holley Weber, it varies from 20% to probably 60%, depending on the carb.
Only down side is its kind of tall compared to a Holley 2-bbl with the air horn removal.
Dak Dak owners have been using them with some weird log adapter set ups for donkey's years. Nah, make that Jack A$$es years...
Here is just some of the Volkswagen 1-bbl Solex adapters for the yet another brace of 5200/5210/5220/6520 2-BBL carbs. Its designed for their log intake single porters, but basically using an adapter like this, your able to hook up to an early Tripower intake, and provide three duces with mechanical secondary's. You find them from old Redline cat no items.
Some are offset, some are really like our 2-bbl to 1-bbl Clifford, Classic Inlines or Stove bolt or Technico items
http://www.thesamba.com/vw/forum/viewtopic.php?t=439577
The more you look, the more you find
This with a Datsun 1200 cc air cleaner
http://images.thesamba.com/vw/gallery/pix/287654.jpg
http://www.thesamba.com/vw/forum/viewtopic.php?t=554902
Then there are the Volkswagen Audi based engines uses in AMC and Mopar's before the 2.2 K car engine.
http://www.3geez.com/forum/carburetor-tech/63189-holley-5200-maybe-another-model.html
AMC – 5210 on the Audi powered ’77 Gremlin
An AMC 8549 1439 tagged item has
Primary Main Jet: 183
Secondary Main Jet: 243
Primary Air Corrector: 125
Secondary Air Corrector: 180
Primary Emulsion Tube: 75
Secondary Emulsion Tube: 74
Then you might find, say R9877 1672.
This looks very much like the rare 2V carb and adaptor Ford
might have used on the 1980 Fox cars, but its actually a VW Beetle Solex 1-bbl verses Holley Weber 5200 2-bbl aftermarket kit.
Here is a Missing in Action Holley Weber 52xx to 65xx List and Makers PN from 1973 until Ford axed the carb in 1983 for the single barrel.
There is an on line list of the 19 (nineteen) Holley Weber carbs in the 445 carb list below,
http://holdenpaedia.oldholden.com/images/HolleyCarb.html
These are appended with the Dave Emanual even more extensive list of 8 (eight) other Holley Webers in Super Tuning and Modifying Holley Carburetors.
There are seven extras just from and afternoon of FEP internet trawling.
Every Holley Weber on the net seams to have a different list number and part number, which is probably as it should be, since the published Holley lists are for carb kits where as real Holley Webers in service are factory list carbs with a automakers unique production part number