On any other engine but a Ford I6, a 100 hp shot would take it out! Good thing is, nitrous is more worried by thermal stress rather than sharp loads on the rods. It's very unlikely a six-potter with standard cam would rev beyond 5000 rpm, and the piston speed even at 5500 rpm is lower than, say, a 327, 350, 351 V8 and way, way below a 225 Chrysler. Cast rods and slugs shouldn't cause a problem!
Only issue I can see is lean conditions for the Excess Fuel Factor. The outer rear cylinder may find going tough because it may not get enough rich fuel to go with the oxygen -liberating nitrous. The front cylinder is over-cooled, so a lean-out shouldn't cause a problem. At the end of the day, number 6 cylinder is a long way from the gasoline scource. Nitrous must have extra cooling gasoline to stop the combustion chamber becoming an expensive gas-axe!
Port water or methanol injection may be another option to ensure that never happens, but I'm gliding off into Weird Six Science here....again!!!