There is a huge change with gradient to the proper operation of a carb. Normal along the road gradients on some of the steeper mounted passes ar 12%, 4 times, normal camber (crossfall) on a road is often 3%. Normal superelevation, (the buildup of the outside of a corner) on a road can go up to 10% on tighter corners. The fuel level in Holley carbs, more than any other carb, has a vast affect on the fuel consumption. If you get the float level out just a little, you can never trace the fault back to anything concrete. The sight glass is designed around the carb being level to the ground, and with a width of 1.875" between both main jets, a 12% grade will alter the stage fuel height by almost a quarter of an inches, the full depth of the sight plug. This is enough to upset the calibration.
I've seen Holley 1-bbls on Offy/Clifford tripple manifolds, but they are mounted like they are on V8's, not spun around like on our sixes.
Angling the carb does change the jetting requirements. A 3.5 degree change in the direct mount 2300 instillation is like driving up a 6% grade all day, very different to the way the Holleys are mounted in the V8 cars.
In our sixes, the power valve and main jets will get closer to getting exposed on an upward 12% gradient, and having a the car mounted flat to the head could result in the carb behaving like it was on a 15% gradient.
Holleys are great carbs, but they have limitations when the going gets rough, steep, or when we side mount them on our sixes. This was not the way Holley intended them to be mounted, and even a few degrees is enough to upset things.