John,
What are you doing?
I'm playing the devil advocate again, don't you think too much air flow ability will exceed what the 300 can best use, moving the flow capabilities above the usable rpm range .
Dad and I once built up a pair of SCJ heads for a 429, flowed like a flush toliet. But on the engine were not as good as before. Went to 460, the heads started to work. But the real kick-in -the-butt came when we went to 514, a whole new world, 5,000# car C-6 running LOW 10.0s
Would it be possible to use some other head design, Trick Flow Twisted wedge or Yates. By using the mirror image it would put the valves in the right sequence. Pistons are available for both, might have to juggle rod length and pin size.
I can see designing so the exhaust ports are in the same place and using existing headers, no problem to increase tubing size. But forget designing intake side to use any existing aftermarket intakes. None are big enough for a truly decent flowing head. You've see the pics of my 300 head, 242cfm and honestly the ID of the intake ports are LARGER than the OD of the Cliffy manifold at the flange. And it is not unusual for a head caster to als cast their own intakes, ala Dart.