Ak Millers four Kiehn set-up looks like the easiest to set up. That way, you can put it back to stock after you've finished.
I'd say start with four Suzuki GSX600 carbs, and use one wide band oxygen sensor and a stable, large diameter gauge which indicates lean to rich in 10 to 17:1 scales at 0.5 intervels.
Use the stock single 1100 or 1946 or 1908 or Carter carb to get you home, and tune on a quad carbs on loney road. The available needle selection is huge, and all you need to do is limit fuel pressure to less 1.5 psi by an external Holley 2300 float bowl which can supply a similar head of fuel as a stock motorcylce fuel tank. You can then use the stock fuel pump.
A quad carb set-up is easier to dial in a package. It is not a port on port, or isolated runner set-up.
As soon as you go to a non isolated runner design, things then get very simple, and they are largley insensitve to venturi size. Jetting is easier, but still not a walk in the park.
If you are able to do the linkages, and get a quad set-up running well, then go to six carbs.
Six carbs on a sixcylinder engine is an Isolated runner set-up. These instilations are very hard to tune well. The venturi sizes, jets and enrichment circuits get very 'finikity' due to pulse tuning reversion waves. They take a wealth of parts to perfect, but always yield a huge power gain with a small sacrifice in economy id tuned well.