Generally speaking, the auto tranny loads the engine less at low RPM than does a stick. Also generally speaking, the auto loses lots of power at low RPM, so the extra advance helps pep it up a bit.
There's often a caveat here, though - the distributors associated with auto trannys also have less centrifugal advance by the 4-6 degrees static difference, so the total advance comes out about the same. That's one reason why, when you look inside the dizzy at the weights, you'll see two different slots, typically 11 and 13 degrees (or so, depending on year). This becomes 22 or 26 degrees at the crank. If you add the 12 degree static timing for the auto to the 22 degrees centrifugal, that's 34 total. If you add the 6 degrees static to the 26 degrees centrifugal for the manual, that's 32 total. These are comfortable numbers for a Ford engineer who has to worry about warranty costs and the like, but may not be best for MPG or HP optimizations.
Often, I have seen auto trannys using manifold vacuum for the distributor (pre-emissions) where there was port vacuum for the manuals, but the springing was lighter in the port vacuum diaphragms for quicker advance when port vacuum was available. The auto version often has stiffer vacuum advance springing for less advance action with the stronger manifold vacuum.
A quick-and-easy MPG boost in heavy traffic can come from switching from port vacuum to manifold vacuum. This will require that you turn down the idle speed stop screw, which in turn uses less gas at idle. I do this with my dual-inline-fours all the time, as the traffic seldoms breaches 40 MPH, so the advance stays high. However, when you stomp on it the manifold vacuum can drop away a little faster than port vacuum might (depending on WHERE in the manifold you take the vacuum from), which might make it seem slightly less peppy until the mechanical advance picks up the slack. This is where extra static advance can help.
...in my opinion.
