Well, I know one thing. the66mustang's conversion will work, because he's a master machinist who can make anything work!
I've seen a 1967 Holden 186 I6, in Hugh MacInnes' early version of Turbochargers, and it had a 45 DCOE Weber carb running 14 pounds per square. Power went up 2.32 times the original. Can't remember the exact figures, but from 75 rwhp as a stock 1-bbl non-turbo to 174 rwhp as a 14 psi turbo rings a bell.
The real issue with High-hp turbos as draw throughs is lack of charge cooling, fuel drop out, and even ignition of the fuel charge in some instances. The LeMans Triumph TR8 Turbo had very serious problems with the draw through charge burning up before the intake manifold. Ooops.
Every one should learn the lesson of the first Olds JetFires. The F85 was well executed, but nobody wanted to use the anti-detonation injection, even though it did 800 mpg. And the early turbos had carbon deposites, more from oil quality and using anti-freeze rather than the alcohol blends GM intended. Running a 10.5:1 compression ratio was a bit daring too! The grunty little 215 engine was a good thing, but invested too much faith in its drivers adherance to service and maintenance schedules.
Also, some carbs, notibly #4150 Holleys, have been renown for fuel puddling causing deposites. The are perfect for a drag car, but I've not seen one favourable report for on the road use. Ak Miller Enterprises had a mod to heat up the area before the turbo housing, running water through it. It seams to me that the bigger 2-bbl and 4-bbl Holley isn't a bad carb, just needs a manifold which can stop the fuel dropping out.
Holley Webers have worked well in low boost draw throughs. So have the 2CG Rochester and 4M Rochester Q'Jet. The pre-EFI Rear wheel drive 3.8 Buick turbo set-up, where the carb sit over to the left of the engine bay in Cutlasses, would be perfect for a lower boost 200 cuber with lots of bonnet space. The turbo could sit where the carby sits, and as long as you have a 1.75" hole log head, you could run up to 15 psi with little mixture distribution problems. The Rochester QJet could sit above the left side of the engine, away from the exhast heat. I've seen some wicked nitrous set ups for these draw throughs.
Renown turbo freak, Mike Vine in Brisbane, refused to sell Holley carbed Turbo cross-flows. He did quite a few draw throughs with twin CD 175's bored out to 1.875", and got 350 hp easily with methonol/water injection and 12 pounds boost and 8:1 compression through a machined head. Remeber, this is a power supply of 2.67 times that of the stock 9.35:1 compression 250 cross-flow's 131 hp! Some twin turbo EFI's got up to 383 hp.
If you follow the rules on how to keep the fuel in suspension, find some method of stopping detonation, and build a 'one-size fits all' ductile iron exhast manifold for anything from a 144 to US 250's and Aussie 250 2V, not a argon back-purged special that will crack and let you down, then you'll get power without hassles.
In Australia, Holden sixes got a semi-factory SL/T 3300 Torana which could do high 15 second quarters with 180 hp, an aftermarket Commodore Turbo, with the same power as a 5.0 liter V8, and these cars were quite good conversions. The growing V8 resurgence from the fuel glutt in 1982 killed them. So did the Nissan 3.0 Turbo Holden used. Ford Turbos were factory run as test cars, but the old boys network, led by Max Gransden, the person who killed the Cleveland V8, the local C4, the Cortina, the local six cylinder 250 Bronco, lost the plot, and gave no aftermarket backing to Ford Turbo projects. Best example was the Mazda GLC/323 based Ford Lazer Turbo. It had an Austrailain Bensons Turbo induction set up, with a Mazda 323 Turbo unit. It was a night mare. Put Ford Aussie out of locally made turbo cars for 20 years. All the Aussie market Ford Turbos were Mazdas until 2003!