I've been wrestling with turbo questions for some time. I'm taking the (hopefully) simple route with a carbureted draw-thru system based on a Buick turbo setup. No intercooler. No electronics, other than boost retard.
In my ideal world, I'd go with sequential electronic fuel injection, blow through and intercooler. But that's generally expensive, complicated and difficult to do on US 200/250 heads. However, I would like to see what could be cobbled together from existing pieces. Throttle body injection in a blow through system? Could a GM or Ford computer be hacked well enough to deal with boost, etc.?
Draw-thru carb systems don't fit well with intercoolers. The suspended fuel can puddle on the long trip through the intercooler and to the engine. I also imagine you could time throttle response with an hour glass. I imagine I'll have to look at water/alcohol injection or some similar option. There's a fair amount of discussion of these options on the draw-thru forum on Yahoo.
Blow-thru carb systems seem to work OK and can use an intercooler. There the problem usually is trying to seal the carb so the boost isn't lost and the carb circuits work properly. There are also blow-thru forums.
I just decided to quit wavering and try something.