We've found (Aussies/Kiwis) that the tubular ones are likely to suffer problems, not the solids. 250's tend to vibrate quite a lot more than the little 200's
Over here, talking X-flows, there was a case when the earlier cast pushrods would hack almost any revs, but the post 1980 ones were dreadfull past 5000 rpm. Anyone doing a back to back comparison with a 200 and then the 250 notices the difference in smoothness. Its sort of like comparing a good 289W to a 351W, the little one is smooth, the big one is a bit of a savage animal, not any extra power, but a lot more torque.
Our 200 cube X-flows ran the same rods as the 250, but even on the smoother 200, at 5500 rpm, the pushrods could still break.
I had my old X-flow with tubr rods up to 5300 rpm and never broke them, but the aftermarket cam profile was pretty soft at 256 degrees.