Darton should be able to come up with an interlocking sleeve set that would allow 4.250 and leave the fill level down 2-3" for some cooling.
The dimensional instability of aluminum, and paper thin factory sleeve columns, is a recipe for failure.
The commercially available block fillers are popular, because they work. If re-melted turkey pot pie tins was a good idea,,,
Steel shot mixed with the cement type fillers, or an epoxy, would add a bit of dampening, I'd suspect.
But, if a big power E85 inliner is the goal, the CNG Cummins should live at 1000hp