An early 200 log head with its stock 1.5" hole is not so good at flowing air fuel mix evenly to each piston. At high boosts, there is evidence a flow distribution occurs, especially on our I6's. It's worse with the early pre 1972 cylinder heads, and gets pretty good for 1976 to 1983 3.3 heads. The direct mount 2-bbl Holley/ Autolite carb conversion adaptor pioneered by the writers of the Ford Falcon performance handbook is very good at adding lots of air fuel mix without any problems with restictive airflow causing some cylinders to be underfed with fuel, others to get too much. That;s the worst situation for preignition of detonating happening.
An engine with stock pistons or stock engine will be able to handle a lot of boost before it blows up, because is only designed for a 300 hour dyno test on a stock engine. If you supercharge or turbo it, you change the load the engine sees at the pistions.